Buy 4 aco dmt (or psilacetin) is a semi-synthetic tryptamine closely related to the “magic mushroom” molecules psilocin and psilocybin. Like psilocybin, it appears to be metabolized by the body into psilocin. Most people buy psilacetin as a brown or off-white powder that can be mixed with water just before dosing. But it’s also available in pills, tablets, capsules, and gel tabs among other preparations. While some find the effects indistinguishable from psilocybin mushrooms, others say it’s more like DMT. The difference may be dose-dependent. But mystical-type experiences are common, as are philosophical insights and a sense of empathic well-being.

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Among the most common effects of 4-AcO-DMT are spiritual or mystical experiences and compassion for the people in one’s life. Openness with family is a recurring theme. One person found the softening of his ego allowed him to have a long-overdue conversation with his brother about their mother’s death.  Finally telling him things that he “should have said much earlier”. He was also able to reconnect and “productively engage” with his father. Another felt similarly empowered, coming to understand the “problematic tension” between himself and his father and resolving “to mend their fractured state.”

Gratitude, acceptance, trust, and letting go are some other common themes. As one psychonaut put it, “whereas mushrooms operate in a part of the brain that could be considered about language or intellect, 4-AcO-DMT acts on the emotional thought processes” . By taking 4-AcO-DMT once every couple of months, he said, he was better able to manage his “warped” emotions.

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As a more stable prodrug of psilocin than psilocybin, and one that’s more easily synthesized. 4-AcO-DMT may be useful for clinical research. It was used, for example, to test the hypothesis that 5-HT2A agonists can alleviate withdrawal symptoms and even prevent addictions from forming. Opiate-dependent rodents given 4-AcO-DMT were effectively cured of their addiction. And a single dose of 4-AcO-DMT given before chronic nicotine exposure blocked their transition to a nicotine-dependent state. How 4-AcO-DMT may be used to treat addiction in humans remains to be seen, but these results support neurobiological theories of dependence—and in particular, the hypothesis that serotonergic agents can be used to regulate underlying mechanisms involving GABA (gamma-aminobutyric acid) receptors and BDNF (brain-derived neurotrophic factor) in the ventral tegmental area of the brain.

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The authors of this study also suggested that 4-AcO-DMT might be useful for the treatment of depression via the same pathway and the regulation of “aberrant glutamatergic activity”.  5-HT2A agonists could offer substantially longer-lasting relief than drugs regulating glutamatergic activity via different pathways, such as the NMDA (N-methyl-D-aspartate) antagonist ketamine. Anecdotal reports appear to lend further support. Whereas prescribed antidepressants can have a “numbing” effect, for instance, 4-AcO-DMT is said to help resolve underlying “emotional damage” . One man was able to overcome his PTSD through just six trips, describing the compound as “life-changing” and likening his experiences with it to “unknotting scar tissue” and rediscovering his “inner confident self”.  Another self-medicator, a victim of childhood abuse, said she was able to work through her trauma with 4-AcO-DMT . She also move on with her life in a way that prescribed medications actively seemed to prevent.

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And yet another, frustrated with conventional antidepressants, credited 4-AcO-DMT with allowing him to “experience happiness and connection,” . While also decreasing his reliance on alcohol. This has seen some argue that the drug is not harmful and should be made legal, but this remains a situation to see.

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